2016 Open d'Orléans – Singles

Jan-Lennard Struff was the defending champion but lost in the first round to Daniil Medvedev.

Pierre-Hugues Herbert won the title after defeating Norbert Gombos 7–5, 4–6, 6–3 in the final.

Seeds
• # 🇺🇦 Illya Marchenko (first round)

• # 🇩🇪 Dustin Brown (quarterfinals)

• # 🇫🇷 Paul-Henri Mathieu (second round)

• # 🇩🇪 Jan-Lennard Struff (first round)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇲🇩 Radu Albot (first round)

• # 🇫🇷 Pierre-Hugues Herbert (champion)

• # 🇺🇿 Denis Istomin (first round)