2016 Open de Nice Côte d'Azur – Singles

Dominic Thiem was the defending champion and successfully defended his title, defeating Alexander Zverev in the final, 6–4, 3–6, 6–0.

Seeds
The top four seeds receive a bye into the second round. • #🇦🇹 Dominic Thiem (champion)

• #🇫🇷 Gilles Simon (quarterfinals)

• # Kevin Anderson (quarterfinals)

• #🇫🇷 Benoît Paire (second round)

• # João Sousa (semifinals)

• #🇮🇹 Fabio Fognini (first round)

• #🇮🇹 Andreas Seppi (quarterfinals)

• #🇩🇪 Alexander Zverev (final)

Seeds
• # 🇦🇷 Diego Schwartzman (qualified)

• # 🇧🇦 Damir Džumhur (first round)

• # 🇺🇸 Donald Young (qualified)

• # 🇬🇧 Kyle Edmund (qualified)

• # 🇮🇹 Marco Cecchinato (qualifying competition)

• # 🇫🇷 Mathias Bourgue (qualifying competition)

• # 🇷🇸 Miljan Zekić (first round)

• # 🇷🇺 Daniil Medvedev (qualified)

Qualifiers
• # 🇦🇷 Diego Schwartzman

• # 🇷🇺 Daniil Medvedev

• # 🇺🇸 Donald Young

• # 🇬🇧 Kyle Edmund