2016 Regional League Division 2 North Eastern Region

2016 Regional League Division 2 North Eastern Region is the 8th season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system. The league winners and runners up will qualify for the 2016 Regional League Division 2 champions league round.

Promoted clubs
Khonkaen United and Ubon UMT United were promoted to the 2016 Thai Division 1 League.

Returning clubs
Yasothon is returning to the league after a 2-year break.

Moved clubs

 * Loei City and Nong Bua Pitchaya were moved to the Northern Region.
 * Chaiyaphum were moved to the Central Region.

Top scorers

 * As of 28 August 2016.