2016 Regional League Division 2 Southern Region

2016 Regional League Division 2 Southern Region is the 8th season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.

Relegated clubs
Phuket were relegated from the 2015 Thai Division 1 League.

Renamed clubs

 * Surat renamed Surat Thani.
 * Satun United renamed Cadenza Satun United.

Relocated club

 * Chumphon moved into the Western Region.

Returning clubs
Hat Yai is returning to the league after a 1-year Withdrawn.

Top scorers

 * As of 3 September 2016.