2016 San Benedetto Tennis Cup – Singles

Albert Ramos Viñolas was the defending champion but chose not to participate.

Federico Gaio won the title after defeating Constant Lestienne 6–2, 1–6, 6–3 in the final.

Seeds
• # 🇮🇹 Alessandro Giannessi (second round, retired)

• # 🇮🇹 Luca Vanni (first round)

• # 🇦🇷 Facundo Argüello (first round)

• # Blaž Rola (second round)

• # 🇧🇪 Arthur De Greef (semifinals)

• # 🇫🇷 Mathias Bourgue (first round)

• # 🇮🇹 Matteo Donati (first round)

• # 🇫🇷 Grégoire Barrère (first round)