2016 Santa Cruz Futebol Clube season

The 2016 season was Santa Cruz's 103rd season in the club's history. Santa Cruz competed in the Campeonato Pernambucano, Copa do Brasil, Copa Sudamericana, Copa do Nordeste and Série A.

Overall
{| class="wikitable"
 * Games played || 73 (14 Pernambucano, 12 Copa do Nordeste, 5 Copa do Brasil, 4 Copa Sudamericana, 38 Série A)
 * Games won || 24 (5 Pernambucano, 7 Copa do Nordeste, 2 Copa do Brasil, 2 Copa Sudamericana, 8 Série A)
 * Games drawn || 19 (6 Pernambucano, 3 Copa do Nordeste, 2 Copa do Brasil, 1 Copa Sudamericana, 7 Série A)
 * Games lost || 30 (3 Pernambucano, 2 Copa do Nordeste, 1 Copa do Brasil, 1 Copa Sudamericana, 23 Série A)
 * Goals scored || 86
 * Goals conceded || 99
 * Goal difference || –13
 * Best results (goal difference) || 5–1 (H) v Grêmio – Série A – 2016.11.27
 * Worst result (goal difference)|| 0–5 (A) v São Paulo – Série A – 2016.12.11
 * Top scorer || Grafite (24)
 * Goals conceded || 99
 * Goal difference || –13
 * Best results (goal difference) || 5–1 (H) v Grêmio – Série A – 2016.11.27
 * Worst result (goal difference)|| 0–5 (A) v São Paulo – Série A – 2016.12.11
 * Top scorer || Grafite (24)
 * Best results (goal difference) || 5–1 (H) v Grêmio – Série A – 2016.11.27
 * Worst result (goal difference)|| 0–5 (A) v São Paulo – Série A – 2016.12.11
 * Top scorer || Grafite (24)
 * Top scorer || Grafite (24)
 * Top scorer || Grafite (24)

Managers performance
(c) Indicates the caretaker manager