2016 Sarasota Open – Singles

Federico Delbonis was the defending champion but chose not to participate.

Mischa Zverev won the title, defeating Gerald Melzer 6–4, 7–6(7–2) in the final.

Seeds
• # 🇺🇸 Denis Kudla (first round)

• # 🇦🇷 Diego Schwartzman (second round)

• # 🇦🇹 Gerald Melzer (final)

• # Nikoloz Basilashvili (first round, retired)

• # 🇺🇸 Tim Smyczek (first round)

• # 🇺🇸 Bjorn Fratangelo (semifinals)

• # 🇦🇷 Facundo Argüello (second round, retired)

• # 🇺🇸 Jared Donaldson (first round)