2016 Slovak Open – Men's singles

Egor Gerasimov was the defending champion but lost in the quarterfinals to Marius Copil.

Norbert Gombos won the title after defeating Copil 7–6(10–8), 4–6, 6–3 in the final.

Seeds
• # 🇩🇪 Florian Mayer (first round)

• # 🇺🇦 Illya Marchenko (second round)

• # 🇨🇿 Adam Pavlásek (quarterfinals)

• # 🇩🇪 Jan-Lennard Struff (second round)

• # 🇨🇿 Lukáš Rosol (first round)

• # 🇷🇺 Daniil Medvedev (semifinals)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇸🇰 Jozef Kovalík (first round)