2016 Trofeo Città di Brescia – Singles

Igor Sijsling was the defending champion but chose not to defend his title.

Luca Vanni won the title after defeating Laurynas Grigelis 6–7(5–7), 6–4, 7–6(10–8) in the final.

Seeds
• # 🇸🇰 Lukáš Lacko (semifinals)

• # 🇨🇿 Lukáš Rosol (withdrew)

• # Marco Chiudinelli (second round)

• # 🇷🇺 Evgeny Donskoy (first round)

• # 🇦🇷 Leonardo Mayer (second round)

• # 🇪🇸 Enrique López-Pérez (first round)

• # 🇷🇺 Alexander Kudryavtsev (second round)

• # 🇷🇸 Marko Tepavac (first round)