2016 Trophée des Alpilles – Singles

Ivan Dodig was the defending champion but chose not to defend his title.

Daniil Medvedev won the title after defeating Joris De Loore 6–3, 6–3 in the final.

Seeds
• # 🇺🇦 Sergiy Stakhovsky (first round)

• # 🇷🇺 Konstantin Kravchuk (semifinals)

• # 🇦🇷 Leonardo Mayer (second round)

• # 🇦🇷 Marco Trungelliti (quarterfinals)

• # 🇩🇪 Tobias Kamke (first round)

• # 🇫🇷 Quentin Halys (quarterfinals)

• # 🇩🇪 Peter Gojowczyk (first round)

• # 🇧🇪 Kimmer Coppejans (first round)