2016 U.S. Men's Clay Court Championships

The 2016 U.S. Men's Clay Court Championships (also known as the Fayez Sarofim & Co. U.S. Men's Clay Court Championships for sponsorship purposes) was a tennis tournament played on outdoor clay courts. It was the 48th edition of the U.S. Men's Clay Court Championships, and an ATP World Tour 250 event on the 2016 ATP World Tour. It took place at River Oaks Country Club in Houston, Texas, United States, from April 4 through April 10, 2016.

Seeds

 * Rankings are as of March 21, 2016.

Other entrants
The following players received wildcards into the main draw:
 * 🇺🇸 Tommy Paul
 * 🇺🇸 Frances Tiafoe
 * 🇺🇸 Tim Smyczek

The following player received entry with a protected ranking:
 * 🇷🇺 Dmitry Tursunov

The following players received entry via the qualifying draw:
 * 🇦🇺 Matthew Barton
 * 🇦🇷 Carlos Berlocq
 * 🇦🇷 Nicolás Kicker
 * 🇩🇪 Mischa Zverev

The following player received entry as a lucky loser:
 * 🇺🇸 Reilly Opelka

Withdrawals

 * Before the tournament
 * Kevin Anderson → replaced by 🇷🇺 Dmitry Tursunov
 * 🇰🇿 Mikhail Kukushkin → replaced by 🇸🇰 Lukáš Lacko
 * 🇦🇷 Leonardo Mayer → replaced by 🇩🇪 Benjamin Becker
 * 🇦🇺 John Millman → replaced by 🇺🇸 Reilly Opelka

Seeds

 * Rankings are as of March 21, 2016.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇳🇿 Marcus Daniell / 🇳🇿 Artem Sitak
 * 🇺🇸 Reilly Opelka / 🇺🇸 Tommy Paul

The following pair received entry as alternates:
 * 🇦🇷 Guido Andreozzi / 🇦🇷 Nicolás Kicker

Withdrawals

 * Before the tournament
 * 🇩🇪 Dustin Brown (wrist injury)


 * During the tournament
 * 🇩🇪 Philipp Petzschner (knee injury)

Singles

 * 🇦🇷 Juan Mónaco defeated 🇺🇸 Jack Sock, 3–6, 6–3, 7–5

Doubles

 * 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan defeated 🇩🇴 Víctor Estrella Burgos / 🇲🇽 Santiago González, 4–6, 6–3, [10–8]