2016 U.S. Men's Clay Court Championships – Singles

Jack Sock was the defending champion, but lost in the final to Juan Mónaco, 6–3, 3–6, 5–7.

Seeds
The top four seeds receive a bye into the second round. • #🇺🇸 John Isner (semifinals)

• #🇫🇷 Benoît Paire (second round)

• #🇪🇸 Feliciano López (semifinals)

• #🇺🇸 Jack Sock (final)

• #🇺🇸 Sam Querrey (quarterfinals)

• #🇺🇸 Steve Johnson (first round)

• #🇨🇾 Marcos Baghdatis (quarterfinals)

• #🇮🇹 Paolo Lorenzi (first round)

Seeds
• # 🇺🇸 Bjorn Fratangelo (qualifying competition)

• # 🇦🇷 Carlos Berlocq (qualified)

• # 🇺🇸 Jared Donaldson (qualifying competition)

• # 🇺🇸 Dennis Novikov (first round)

• # 🇦🇷 Nicolás Kicker (qualified)

• # 🇩🇪 Mischa Zverev (qualified)

• # 🇦🇷 Guido Andreozzi (first round)

• # 🇧🇷 Guilherme Clezar (first round)

Qualifiers
• # 🇩🇪 Mischa Zverev

• # 🇦🇷 Carlos Berlocq

• # 🇦🇷 Nicolás Kicker

• # 🇦🇺 Matthew Barton

Lucky losers
• # 🇺🇸 Reilly Opelka