2016 US Open – Boys' singles

Taylor Harry Fritz was the defending champion, but is no longer eligible to compete.

Félix Auger-Aliassime won the title, defeating Miomir Kecmanović in the final, 6–3, 6–0.

Seeds
• # Stefanos Tsitsipas (semifinals)

• # 🇦🇺 Alex De Minaur (second round)

• # 🇺🇸 Ulises Blanch (second round)

• # 🇫🇷 Geoffrey Blancaneaux (second round)

• # 🇷🇸 Miomir Kecmanović (final)

• # 🇨🇦 Félix Auger-Aliassime (champion)

• # 🇯🇵 Yosuke Watanuki (semifinals)

• # 🇦🇷 Genaro Alberto Olivieri (second round)

• # 🇨🇦 Benjamin Sigouin (first round)

• # 🇺🇸 John McNally (first round)

• # 🇪🇪 Kenneth Raisma (quarterfinals)

• # 🇪🇬 Youssef Hossam (third round)

• # 🇪🇸 Nicola Kuhn (quarterfinals)

• # 🇩🇪 Marvin Möller (third round)

• # 🇨🇳 Wu Yibing (first round)

• # 🇩🇪 Louis Wessels (second round)

Seeds
• # 🇨🇳 Zhao Lingxi (first round)

• # 🇯🇵 Naoki Tajima (first round)

• # 🇧🇪 Zizou Bergs (first round)

• # 🇸🇪 Jonas Eriksson Ziverts (qualified)

• # 🇭🇰 Anthony Jackie Tang (first round)

• # 🇷🇺 Mikhail Sokolovskiy (first round)

• # 🇧🇷 Lucas Koelle (qualifying competition)

• # 🇺🇦 Nikita Mashtakov (qualifying competition)

• # 🇫🇷 Constantin Bittoun Kouzmine (qualified)

• # 🇧🇪 Seppe Cuypers (first round)

• # 🇫🇷 Constant de la Bassetière (first round)

• # 🇮🇹 Riccardo Balzerani (qualified)

• # 🇨🇦 Jack Mingjie Lin (qualifying competition)

• # 🇮🇹 Andrea Guerrieri (qualified)

• # 🇪🇪 Mattias Siimar (qualifying competition)

• # 🇧🇬 Alexander Donski (qualifying competition)

Qualifiers
• # 🇫🇷 Constantin Bittoun Kouzmine

• # 🇮🇹 Enrico Dalla Valle

• # 🇮🇹 Andrea Guerrieri

• # 🇸🇪 Jonas Eriksson Ziverts

• # 🇺🇸 Patrick Kypson

• # 🇺🇸 Olukayode Ayeni

• # 🇯🇵 Yuta Kikuchi

• # 🇮🇹 Riccardo Balzerani