2016 US Open – Women's doubles

Martina Hingis and Sania Mirza were the defending champions, but chose not to participate together. Mirza teamed up with Barbora Strýcová, but lost in the quarterfinals to Caroline Garcia and Kristina Mladenovic. Hingis played alongside CoCo Vandeweghe, but lost in the semifinals to Garcia and Mladenovic.

Bethanie Mattek-Sands and Lucie Šafářová won the title, defeating Garcia and Mladenovic in the final, 2–6, 7–6(7–5), 6–4. It was their third Grand Slam title together.

Seeds
• 🇫🇷 Caroline Garcia / 🇫🇷 Kristina Mladenovic (final)

• Chan Hao-ching /  Chan Yung-jan (second round)

• 🇭🇺 Tímea Babos / 🇰🇿 Yaroslava Shvedova (third round)

• 🇨🇿 Andrea Hlaváčková / 🇨🇿 Lucie Hradecká (third round)

• 🇷🇺 Ekaterina Makarova / 🇷🇺 Elena Vesnina (semifinals)

•  Martina Hingis / 🇺🇸 CoCo Vandeweghe (semifinals)

• 🇮🇳 Sania Mirza / 🇨🇿 Barbora Strýcová (quarterfinals)

• 🇩🇪 Julia Görges / 🇨🇿 Karolína Plíšková (third round)

• 🇺🇸 Raquel Atawo / 🇺🇸 Abigail Spears (first round)

• 🇺🇸 Vania King / 🇷🇴 Monica Niculescu (third round)

• 🇨🇳 Xu Yifan / 🇨🇳 Zheng Saisai (third round)

• 🇺🇸 Bethanie Mattek-Sands / 🇨🇿 Lucie Šafářová (champions)

•  Andreja Klepač /  Katarina Srebotnik (quarterfinals)

•  Darija Jurak / 🇦🇺 Anastasia Rodionova (second round)

•  Kiki Bertens / 🇸🇪 Johanna Larsson (second round)

• 🇨🇿 Barbora Krejčíková / 🇨🇿 Kateřina Siniaková (quarterfinals)

Wild cards
• 🇺🇸 Brooke Austin / 🇺🇸 Kourtney Keegan

• 🇺🇸 Catherine Bellis / 🇺🇸 Julia Boserup

• 🇺🇸 Jacqueline Cako / 🇺🇸 Danielle Lao

• 🇺🇸 Samantha Crawford / 🇺🇸 Jessica Pegula

• 🇺🇸 Jada Hart / 🇺🇸 Ena Shibahara

• 🇺🇸 Asia Muhammad / 🇺🇸 Taylor Townsend

• 🇺🇸 Ashley Weinhold / 🇺🇸 Caitlin Whoriskey

Protected ranking
• Michaëlla Krajicek / 🇬🇧 Heather Watson

Alternates
• 🇨🇳 Han Xinyun / 🇨🇳 Zhang Kailin

• 🇯🇵 Kurumi Nara / 🇯🇵 Naomi Osaka

• 🇹🇭 Varatchaya Wongteanchai / 🇨🇳 Yang Zhaoxuan