2016 Uruguay Open – Singles

Guido Pella was the defending champion but chose not to defend his title.

Diego Schwartzman won the title after defeating Rogério Dutra Silva 6–4, 6–1 in the final.

Seeds
• # 🇪🇸 Nicolás Almagro (quarterfinals)

• # 🇦🇷 Diego Schwartzman (champion)

• # 🇦🇷 Horacio Zeballos (quarterfinals)

• # 🇪🇸 Íñigo Cervantes (quarterfinals)

• # 🇦🇷 Carlos Berlocq (semifinals, retired)

• # 🇧🇷 Rogério Dutra Silva (final)

• # 🇦🇷 Guido Andreozzi (second round, retired)

• # 🇦🇷 Nicolás Kicker (quarterfinals)