2016 Winston-Salem Open

The 2016 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 48th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP World Tour 250 Series of the 2016 ATP World Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 23 through August 29, 2015. It was the last event on the 2016 US Open Series before the 2016 US Open.

Seeds

 * Rankings are as of August 15, 2016

Other entrants
The following players received wildcards into the singles main draw:
 * 🇪🇸 Roberto Bautista Agut
 * 🇺🇸 Bjorn Fratangelo
 * 🇺🇸 Rajeev Ram
 * 🇺🇸 Frances Tiafoe

The following player received entry using a protected ranking:
 * 🇦🇺 Thanasi Kokkinakis

The following players received entry from the qualifying draw:
 * 🇲🇩 Radu Albot
 * 🇦🇺 James Duckworth
 * 🇮🇪 James McGee
 * 🇯🇵 Yoshihito Nishioka

The following player received entry as a lucky loser:
 * Tim van Rijthoven

Withdrawals

 * Before the tournament
 * Borna Ćorić →replaced by 🇬🇧 Daniel Evans
 * 🇪🇸 Marcel Granollers →replaced by 🇩🇴 Víctor Estrella Burgos
 * Ernests Gulbis →replaced by 🇫🇷 Pierre-Hugues Herbert
 * 🇫🇷 Nicolas Mahut →replaced by 🇨🇿 Lukáš Rosol
 * 🇦🇷 Juan Mónaco →replaced by 🇷🇺 Evgeny Donskoy
 * 🇫🇷 Benoît Paire →replaced by 🇧🇦 Damir Džumhur
 * 🇦🇷 Guido Pella →replaced by 🇫🇷 Stéphane Robert
 * 🇮🇱 Dudi Sela →replaced by 🇩🇪 Jan-Lennard Struff
 * 🇦🇷 Horacio Zeballos →replaced by Tim van Rijthoven


 * During the tournament
 * 🇷🇺 Mikhail Youzhny

Retirements

 * 🇨🇿 Jiří Veselý

Seeds

 * Rankings are as of August 15, 2016

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇩🇪 Andre Begemann / 🇮🇳 Leander Paes
 * 🇹🇳 Skander Mansouri / 🇩🇪 Christian Seraphim

Singles

 * 🇪🇸 Pablo Carreño Busta def. 🇪🇸 Roberto Bautista Agut, 6–7(6–8), 7–6(7–1), 6–4

Doubles

 * 🇪🇸 Guillermo García López / 🇫🇮 Henri Kontinen def. 🇩🇪 Andre Begemann / 🇮🇳 Leander Paes, 4–6, 7–6(8–6), [10–8]