2017 San Luis Open Challenger Tour – Singles

Peđa Krstin was the defending champion but lost in the first round to Caio Zampieri.

Andrej Martin won the title after defeating Adrián Menéndez Maceiras 7–5, 6–4 in the final.

Seeds
• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇦🇹 Gerald Melzer (quarterfinals)

• # 🇺🇸 Stefan Kozlov (first round)

• # 🇧🇷 João Souza (second round)

• # 🇸🇰 Andrej Martin (champion)

• # 🇪🇬 Mohamed Safwat (first round)

• # Marcelo Arévalo (quarterfinals)

• # 🇪🇸 Adrián Menéndez Maceiras (final)