2017 US Open – Wheelchair women's singles

Yui Kamiji defeated Diede de Groot in the final, 7–5, 6–2 to win the women's singles wheelchair tennis title at the 2017 US Open. It was the first of seven consecutive years where Kamiji and de Groot would meet in the final, and as of 2023 the final remains de Groot's only singles defeat at the US Open.

Jordanne Whiley was the reigning champion from when the event was last held in 2015, but did not participate this year due to pregnancy. The event was not held in 2016 due to a schedule conflict with the 2016 Summer Paralympics.

Seeds
• #🇯🇵 Yui Kamiji (champion)

• # Diede de Groot (final)