2017 US Open – Women's singles

Sloane Stephens defeated Madison Keys in the final, 6–3, 6–0 to win the women's singles tennis title at the 2017 US Open. It was her first major title. Stephens became the first player using a protected ranking to win a major title, and the second unseeded woman in the Open Era to win the US Open (after Kim Clijsters in 2009). It was the first all-American final at the US Open since 2002, and for the first time at a major since the 1985 Wimbledon Championships, all four semifinalists were American, and all from the same country overall.

Angelique Kerber was the defending champion, but was defeated in the first round by Naomi Osaka. Kerber became the second US Open defending champion to lose in the first round, after Svetlana Kuznetsova in 2005. Osaka herself would go on to win the title the next year.

Garbiñe Muguruza became the new world No. 1 despite losing in the fourth round, after Karolína Plíšková failed to defend her finalist points. Eight of the top nine seeds (with the exception of Kerber) were in contention for the top ranking.

This was Maria Sharapova's first major since the 2016 Australian Open, following a suspension for violating anti-doping rules. She was awarded a wildcard into the main draw, and was defeated by Anastasija Sevastova in the fourth round. Venus Williams became the first player in history to reach the semifinals of the US Open 10 years apart and then do so another 10 years apart (1997, 2007, and 2017). Kaia Kanepi became the first qualifier to reach the quarterfinals since Barbara Gerken in 1981, and was the lowest-ranked player ever to reach a major quarterfinal, having been ranked No. 418 prior to the tournament.

This was the final major appearance for former world No. 1 Jelena Janković, who lost to Petra Kvitová in the first round. Janković would formally retire from tennis five years later.

Seeds
• 🇨🇿 Karolína Plíšková (quarterfinals)

• 🇷🇴 Simona Halep (first round)

• 🇪🇸 Garbiñe Muguruza (fourth round)

• 🇺🇦 Elina Svitolina (fourth round)

• Caroline Wozniacki (second round)

• 🇩🇪 Angelique Kerber (first round)

• 🇬🇧 Johanna Konta (first round)

• 🇷🇺 Svetlana Kuznetsova (second round)

• 🇺🇸 Venus Williams (semifinals)

• 🇵🇱 Agnieszka Radwańska (third round)

• 🇸🇰 Dominika Cibulková (second round)

•  Jeļena Ostapenko (third round)

• 🇨🇿 Petra Kvitová (quarterfinals)

• 🇫🇷 Kristina Mladenovic (first round)

• 🇺🇸 Madison Keys (final)

•  Anastasija Sevastova (quarterfinals)

• 🇷🇺 Elena Vesnina (third round)

• 🇫🇷 Caroline Garcia (third round)

• 🇷🇺 Anastasia Pavlyuchenkova (first round)

• 🇺🇸 CoCo Vandeweghe (semifinals)

•  Ana Konjuh (first round)

• 🇨🇳 Peng Shuai (second round)

• 🇨🇿 Barbora Strýcová (second round)

•  Kiki Bertens (first round)

• 🇦🇺 Daria Gavrilova (second round)

• 🇪🇪 Anett Kontaveit (first round)

• 🇨🇳 Zhang Shuai (third round)

• 🇺🇦 Lesia Tsurenko (first round)

•  Mirjana Lučić-Baroni (second round)

• 🇩🇪 Julia Görges (fourth round)

• 🇸🇰 Magdaléna Rybáriková (third round)

• 🇺🇸 Lauren Davis (first round)

Seeded players
The following are the seeded players. Seeds are based on the rankings as of August 21, 2017. Rank and points before are as of August 28, 2017.

Withdrawn players
The following players would have been seeded, but they were not entered or withdrew from the event.

Wild cards
• 🇺🇸 Kayla Day

• 🇫🇷 Amandine Hesse

• 🇺🇸 Sofia Kenin

• 🇺🇸 Ashley Kratzer

• 🇺🇸 Brienne Minor

• 🇦🇺 Arina Rodionova

• 🇷🇺 Maria Sharapova

• 🇺🇸 Taylor Townsend

Protected ranking
• 🇯🇵 Misa Eguchi (109)

• 🇩🇪 Sabine Lisicki (92)

• 🇺🇸 Sloane Stephens (26) (champion)

• 🇦🇺 Ajla Tomljanović (75)

Qualifiers
• 🇷🇺 Anna Blinkova

• 🇷🇴 Mihaela Buzărnescu

• 🇺🇸 Nicole Gibbs

• 🇪🇪 Kaia Kanepi

• Lesley Kerkhove

• 🇺🇸 Allie Kiick

• 🇺🇦 Kateryna Kozlova

• 🇸🇰 Viktória Kužmová

• 🇺🇸 Danielle Lao

• 🇺🇸 Claire Liu

• 🇨🇿 Tereza Martincová

• 🇸🇪 Rebecca Peterson

• 🇹🇷 İpek Soylu

• 🇺🇸 Sachia Vickery

• 🇩🇪 Anna Zaja

• 🇷🇺 Sofya Zhuk

Withdrawals
• † 🇺🇸 Serena Williams (9) → replaced by Richèl Hogenkamp (99)

• † 🇩🇪 Laura Siegemund (36) → replaced by 🇧🇾 Aliaksandra Sasnovich (100)

• † 🇰🇿 Yaroslava Shvedova (83) → replaced by 🇧🇪 Alison Van Uytvanck (101)

• † 🇺🇸 Bethanie Mattek-Sands (90) → replaced by 🇹🇳 Ons Jabeur (102)

• † 🇸🇰 Kristína Kučová (95) → replaced by Viktorija Golubic (103)

• † 🇱🇺 Mandy Minella (104) → replaced by 🇺🇸 Julia Boserup (105)

• & 🇮🇹 Sara Errani (87) → replaced by 🇨🇿 Denisa Allertová (106)

• & Timea Bacsinszky (23) → replaced by 🇫🇷 Pauline Parmentier (107)

• & 🇩🇪 Anna-Lena Friedsam (50 PR) → replaced by 🇷🇴 Ana Bogdan (108)

• & 🇦🇺 Samantha Stosur (38) → replaced by 🇩🇪 Annika Beck (109)

• & 🇧🇾 Victoria Azarenka (6 PR) → replaced by 🇯🇵 Misa Eguchi (109 PR)

† – not included on entry list & – withdrew from entry list