2018 ATP Lyon Open

The 2018 Lyon Open (also known as the Open Parc Auvergne-Rhône-Alpes Lyon) was a men's tennis tournament played on outdoor clay courts. It was the second edition of the Lyon Open and part of the ATP World Tour 250 series of the 2018 ATP World Tour. It took place in the city of Lyon, France, from May 20 through May 26, 2018.

Seeds

 * Rankings are as of May 14, 2018.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇫🇷 Grégoire Barrère
 * 🇫🇷 Adrian Mannarino
 * 🇫🇷 Corentin Moutet

The following players received entry from the qualifying draw:
 * 🇷🇸 Laslo Đere
 * 🇩🇴 José Hernández-Fernández
 * 🇸🇰 Filip Horanský
 * 🇪🇸 Jordi Samper-Montaña

The following players received entry as lucky losers:
 * 🇦🇷 Federico Coria
 * 🇧🇪 Joris De Loore

Withdrawals

 * Before the tournament
 * 🇰🇷 Chung Hyeon → replaced by 🇧🇪 Joris De Loore
 * 🇷🇺 Karen Khachanov → replaced by 🇬🇧 Cameron Norrie
 * 🇦🇷 Leonardo Mayer → replaced by 🇰🇿 Mikhail Kukushkin
 * 🇷🇺 Daniil Medvedev → replaced by 🇷🇸 Dušan Lajović
 * 🇷🇸 Viktor Troicki → replaced by 🇫🇷 Calvin Hemery
 * 🇫🇷 Jo-Wilfried Tsonga → replaced by 🇦🇷 Federico Coria

Seeds

 * Rankings are as of May 14, 2018.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇫🇷 Grégoire Barrère / 🇫🇷 Tristan Lamasine
 * 🇫🇷 Jonathan Eysseric / 🇫🇷 Hugo Nys

Singles

 * 🇦🇹 Dominic Thiem defeated 🇫🇷 Gilles Simon, 3–6, 7–6(7–2), 6–1

Doubles

 * 🇦🇺 Nick Kyrgios / 🇺🇸 Jack Sock defeated 🇨🇿 Roman Jebavý / Matwé Middelkoop, 7–5, 2–6, [11–9]