2018 ATP Lyon Open – Singles

Jo-Wilfried Tsonga was the defending champion, but due to injury did not defend his title.

Dominic Thiem won the title, defeating Gilles Simon in the final, 3–6, 7–6(7–2), 6–1.

Seeds
The top four seeds receive a bye into the second round. • #🇦🇹 Dominic Thiem (champion)

• #🇺🇸 John Isner (quarterfinals)

• #🇺🇸 Jack Sock (second round)

• #🇰🇷 Chung Hyeon (withdrew)

• #🇫🇷 Adrian Mannarino (first round)

• #🇫🇷 Gaël Monfils (first round)

• # João Sousa (first round)

• #🇦🇺 John Millman (withdrew)

Seeds
• # 🇷🇸 Laslo Đere (qualified)

• # 🇪🇨 Roberto Quiroz (first round)

• # 🇩🇴 José Hernández-Fernández (qualified)

• # 🇨🇴 Alejandro González (first round)

• # 🇫🇷 Maxime Janvier (first round)

• # 🇨🇦 Steven Diez (first round)

• # 🇦🇷 Federico Coria (qualifying competition, lucky loser)

• # 🇷🇺 Evgeny Karlovskiy (first round)

Qualifiers
• # 🇷🇸 Laslo Đere

• # 🇸🇰 Filip Horanský

• # 🇩🇴 José Hernández-Fernández

• # 🇪🇸 Jordi Samper Montaña

Lucky losers
• # 🇦🇷 Federico Coria

• # 🇧🇪 Joris De Loore