2018 Abierto Mexicano Telcel – Men's singles

Sam Querrey was the defending champion, but lost in the first round to Matthew Ebden.

Juan Martín del Potro won the title, defeating Kevin Anderson in the final, 6–4, 6–4.

Seeds
• #🇪🇸 Rafael Nadal (withdrew)

• #🇩🇪 Alexander Zverev (semifinals)

• #🇦🇹 Dominic Thiem (quarterfinals)

• #🇺🇸 Jack Sock (first round)

• # Kevin Anderson (final)

• #🇦🇷 Juan Martín del Potro (champion)

• #🇺🇸 Sam Querrey (first round)

• #🇺🇸 John Isner (first round)

Seeds
• # 🇯🇵 Taro Daniel (qualifying competition, lucky loser)

• # 🇱🇹 Ričardas Berankis (qualified)

• # 🇬🇧 Cameron Norrie (qualified)

• # 🇺🇸 Ernesto Escobedo (qualified)

• # 🇰🇿 Alexander Bublik (qualified)

• # 🇮🇳 Ramkumar Ramanathan (first round)

• # 🇺🇸 Mackenzie McDonald (qualifying competition, lucky loser)

• # 🇺🇸 Denis Kudla (qualifying competition)

Qualifiers
• # 🇰🇿 Alexander Bublik

• # 🇱🇹 Ričardas Berankis

• # 🇬🇧 Cameron Norrie

• # 🇺🇸 Ernesto Escobedo

Lucky losers
• # 🇯🇵 Taro Daniel

• # 🇺🇸 Mackenzie McDonald