2018 Abierto Mexicano Telcel – Women's singles

Lesia Tsurenko was the defending champion and successfully defended her title, defeating Stefanie Vögele in the final, 5–7, 7–6(7–2), 6–2.

Seeds
• #🇺🇸 Sloane Stephens (quarterfinals)

• #🇫🇷 Kristina Mladenovic (quarterfinals)

• #🇦🇺 Daria Gavrilova (semifinals)

• #🇨🇳 Zhang Shuai (quarterfinals)

• #🇷🇴 Irina-Camelia Begu (second round)

• #🇫🇷 Alizé Cornet (first round)

• #🇺🇦 Lesia Tsurenko (champion)

• #🇩🇪 Tatjana Maria (first round)

Seeds
• # Jana Fett (qualified)

• # Arantxa Rus (qualified)

• # Jil Teichmann (moved to main draw)

• # 🇸🇪 Rebecca Peterson (qualified)

• # 🇨🇦 Carol Zhao (qualifying competition)

• # 🇨🇿 Tereza Martincová (qualifying competition, retired)

• # 🇦🇺 Olivia Rogowska (qualifying competition)

• # 🇺🇸 Jamie Loeb (qualifying competition)

• # 🇮🇹 Jasmine Paolini (qualified)

• # 🇺🇦 Dayana Yastremska (qualified)

• # 🇨🇿 Marie Bouzková (qualifying competition)

• # Dalila Jakupović (first round)

Qualifiers
• # Jana Fett

• # Arantxa Rus

• # 🇮🇹 Jasmine Paolini

• # 🇸🇪 Rebecca Peterson

• # 🇺🇦 Dayana Yastremska

• # 🇫🇷 Amandine Hesse