2018 Advantage Cars Prague Open – Men's singles

The men's singles of the 2018 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.

Andrej Martin was the defending champion but chose not to defend his title.

Lukáš Rosol won the title after defeating Aleksandr Nedovyesov 4–6, 6–3, 6–4 in the final.

Seeds
• # 🇩🇪 Yannick Maden (second round)

• # 🇧🇷 Rogério Dutra Silva (second round)

• # 🇩🇪 Mats Moraing (quarterfinals)

• # 🇪🇸 Enrique López Pérez (quarterfinals)

• # 🇨🇿 Adam Pavlásek (first round)

• # 🇭🇺 Attila Balázs (first round)

• # 🇩🇪 Oscar Otte (second round)

• # 🇪🇸 Pedro Martínez (semifinals)