2018 Barcelona Open Banco Sabadell – Singles

Two-time defending champion Rafael Nadal defeated Stefanos Tsitsipas in the final, 6–2, 6–1 to win the singles tennis title at the 2018 Barcelona Open. Nadal did not drop a set en route to his record-extending eleventh Barcelona Open title and his 20th ATP 500 title overall, equaling Roger Federer's record. He retained the world No. 1 singles ranking with the win. It was Tsitsipas' first ATP Tour final.

Seeds
All seeds received a bye into the second round. • 🇪🇸 Rafael Nadal (champion)

• 🇧🇬 Grigor Dimitrov (quarterfinals)

• 🇦🇹 Dominic Thiem (quarterfinals)

• 🇧🇪 David Goffin (semifinals)

• 🇪🇸 Pablo Carreño Busta (semifinals)

• 🇷🇸 Novak Djokovic (second round)

• 🇦🇷 Diego Schwartzman (second round)

• 🇪🇸 Roberto Bautista Agut (quarterfinals)

• 🇰🇷 Chung Hyeon (withdrew)

• 🇪🇸 Albert Ramos Viñolas (third round)

• 🇫🇷 Adrian Mannarino (third round)

• 🇪🇸 Feliciano López (third round)

• 🇷🇺 Andrey Rublev (withdrew)

• 🇯🇵 Kei Nishikori (second round, retired)

• 🇪🇸 Fernando Verdasco (withdrew)

• 🇷🇺 Karen Khachanov (third round)

Seeds
• # 🇺🇸 Bjorn Fratangelo (qualified)

• # 🇧🇾 Ilya Ivashka (qualified)

• # 🇧🇷 Rogério Dutra Silva (qualified)

• # 🇸🇰 Martin Kližan (qualified)

• # 🇷🇺 Alexey Vatutin (qualifying competition, lucky loser)

• # 🇸🇰 Andrej Martin (first round)

• # 🇫🇷 Corentin Moutet (qualified)

• # 🇺🇸 Ernesto Escobedo (qualifying competition, lucky loser)

• # 🇸🇰 Jozef Kovalík (qualifying competition, lucky loser)

• # 🇪🇸 Pablo Andújar (qualifying competition, lucky loser)

• # 🇩🇪 Matthias Bachinger (first round)

• # 🇩🇪 Dustin Brown (qualifying competition)

Qualifiers
• # 🇺🇸 Bjorn Fratangelo

• # 🇧🇾 Ilya Ivashka

• # 🇧🇷 Rogério Dutra Silva

• # 🇸🇰 Martin Kližan

• # 🇫🇷 Corentin Moutet

• # 🇪🇸 Ricardo Ojeda Lara

Lucky losers
• # 🇷🇺 Alexey Vatutin

• # 🇺🇸 Ernesto Escobedo

• # 🇸🇰 Jozef Kovalík

• # 🇪🇸 Pablo Andújar