2018 Challenger Ciudad de Guayaquil – Singles

Gerald Melzer was the defending champion but lost in the first round to Federico Coria.

Guido Andreozzi won the title after defeating Pedro Sousa 7–5, 1–6, 6–4 in the final.

Seeds
• # Pablo Cuevas (quarterfinals)

• # 🇦🇷 Federico Delbonis (withdrew)

• # 🇦🇷 Guido Andreozzi (champion)

• # Christian Garín (withdrew)

• # 🇮🇹 Paolo Lorenzi (second round)

• # 🇧🇷 Thiago Monteiro (first round)

• # 🇧🇴 Hugo Dellien (second round)

• # 🇦🇷 Juan Ignacio Londero (quarterfinals)