2018 Charlottesville Men's Pro Challenger – Singles

Tim Smyczek was the defending champion but lost in the second round to Thai-Son Kwiatkowski.

Tommy Paul won the title after defeating Peter Polansky 6–2, 6–2 in the final.

Seeds
• # 🇺🇸 Bradley Klahn (semifinals)

• # 🇺🇸 Michael Mmoh (quarterfinals)

• # Ivo Karlović (quarterfinals)

• # Lloyd Harris (first round)

• # 🇺🇸 Tim Smyczek (second round)

• # Jason Jung (first round)

• # 🇺🇸 Noah Rubin (first round)

• # 🇨🇦 Peter Polansky (final)