2018 Città di Como Challenger – Singles

Pedro Sousa was the defending champion but lost in the first round to Cristian Garín.

Salvatore Caruso won the title after defeating Garín 7–5, 6–4 in the final.

Seeds
• # 🇸🇰 Martin Kližan (quarterfinals)

• # 🇧🇴 Hugo Dellien (first round)

• # Pedro Sousa (first round)

• # 🇧🇷 Thiago Monteiro (first round)

• # 🇦🇷 Juan Ignacio Londero (quarterfinals)

• # 🇫🇷 Stéphane Robert (first round)

• # Gastão Elias (first round)

• # 🇧🇷 Rogério Dutra Silva (first round)