2018 Delray Beach Open – Singles

Jack Sock was the defending champion, but lost in the second round to Reilly Opelka.

Frances Tiafoe won his first ATP World Tour title, defeating Peter Gojowczyk in the final, 6–1, 6–4.

Seeds
• #🇺🇸 Jack Sock (second round)

• #🇦🇷 Juan Martín del Potro (second round)

• # Kevin Anderson (withdrew)

• #🇺🇸 Sam Querrey (first round)

• #🇦🇺 Nick Kyrgios (withdrew)

• #🇺🇸 John Isner (second round)

• #🇫🇷 Adrian Mannarino (withdrew)

• #🇰🇷 Chung Hyeon (quarterfinals)

• #🇨🇦 Milos Raonic (second round)

Seeds
• # 🇺🇸 Bjorn Fratangelo (qualifying competition)

• # 🇬🇧 Cameron Norrie (qualifying competition, lucky loser)

• # 🇺🇸 Tim Smyczek (first round)

• # Henri Laaksonen (first round)

• # 🇪🇸 Adrián Menéndez Maceiras (first round)

• # 🇰🇿 Alexander Bublik (qualified)

• # 🇺🇸 Ernesto Escobedo (first round, retired)

• # 🇮🇳 Ramkumar Ramanathan (qualified)

Qualifiers
• # 🇮🇳 Ramkumar Ramanathan

• # 🇦🇺 John-Patrick Smith

• # 🇰🇿 Alexander Bublik

• # Franko Škugor

Lucky losers
• # 🇬🇧 Cameron Norrie

• # Darian King

• # 🇨🇦 Peter Polansky