2018 Ecuador Open Quito – Singles

Víctor Estrella Burgos was the three-time defending champion and the tournament's only champion to date, but lost in the second round to Gerald Melzer.

Roberto Carballés Baena won his first ATP title, defeating Albert Ramos Viñolas in the final, 6–3, 4–6, 6–4.

Seeds
The top four seeds receive a bye into the second round. • #🇪🇸 Pablo Carreño Busta (second round)

• #🇪🇸 Albert Ramos Viñolas (final)

• #🇫🇷 Gaël Monfils (quarterfinals)

• #🇮🇹 Paolo Lorenzi (second round)

• #🇦🇷 Horacio Zeballos (first round)

• #🇩🇴 Víctor Estrella Burgos (second round)

• # Ivo Karlović (second round)

• # Nicolás Jarry (quarterfinals)

Seeds
The top two seeds receive a bye into the qualifying competition. • # 🇪🇸 Roberto Carballés Baena (qualified)

• # 🇸🇰 Andrej Martin (qualified)

• # 🇮🇹 Alessandro Giannessi (qualifying competition, lucky loser)

• # 🇦🇷 Facundo Bagnis (qualified)

• # 🇧🇷 Guilherme Clezar (first round)

• # 🇧🇷 João Souza (qualifying competition)

• # 🇮🇹 Federico Gaio (qualified)

• # 🇪🇸 Daniel Muñoz de la Nava (first round)

Qualifiers
• # 🇪🇸 Roberto Carballés Baena

• # 🇸🇰 Andrej Martin

• # 🇮🇹 Federico Gaio

• # 🇦🇷 Facundo Bagnis

Lucky loser

 * 1) 🇮🇹 Alessandro Giannessi