2018 FIFA World Cup qualification – CAF second round

The second round of CAF matches for 2018 FIFA World Cup qualification was played from 11 to 17 November 2015.

Format
A total of 40 teams (teams ranked 1–27 in the CAF entrant list and 13 first round winners) played home-and-away over two legs. The 20 winners advanced to the third round.

Seeding
The draw for the second round was held as part of the 2018 FIFA World Cup Preliminary Draw on 25 July 2015, starting 18:00 MSK (UTC+3), at the Konstantinovsky Palace in Strelna, Saint Petersburg, Russia.

The seeding was based on the FIFA World Rankings of July 2015 (shown in parentheses). The 27 direct qualifiers are seeded into three pots:
 * Pot 1 contained the teams ranked 1–13.
 * Pot 2 contained the teams ranked 14–20.
 * Pot 3 contained the teams ranked 21–27.

Each tie contained a team from Pot 1 and a first round winner (first 13 ties) which were automatically allocated into each tie (winner of first round tie 1 into second round tie 1, etc.), or a team from Pot 2 and a team from Pot 3 (last seven ties), with the team from Pot 1 or Pot 2 hosting the second leg. As the draw was held before the first round was played, the identities of the first round winners were not known at the time of the draw.

Note: Bolded teams qualified for the third round.

Matches

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Cameroon won 3–0 on aggregate and advanced to the third round.

Tunisia won 4–2 on aggregate and advanced to the third round.

Guinea won 3–0 on aggregate and advanced to the third round.

Congo won 6–4 on aggregate and advanced to the third round.

Egypt won 4–1 on aggregate and advanced to the third round.

Ghana won 2–0 on aggregate and advanced to the third round.

Nigeria won 2–0 on aggregate and advanced to the third round.

Mali won 3–2 on aggregate and advanced to the third round.

DR Congo won 6–2 on aggregate and advanced to the third round.

Ivory Coast won 4–0 on aggregate and advanced to the third round.

Senegal won 5–2 on aggregate and advanced to the third round.

Cape Verde won 2–1 on aggregate and advanced to the third round.

Algeria won 9–2 on aggregate and advanced to the third round.

Zambia won 3–0 on aggregate and advanced to the third round.

Libya won 4–1 on aggregate and advanced to the third round.

Morocco won 2–1 on aggregate and advanced to the third round.

1–1 on aggregate. Gabon won the penalty shoot-out 4–3 and advanced to the third round.

Burkina Faso won 3–2 on aggregate and advanced to the third round.

Uganda won 4–0 on aggregate and advanced to the third round.

South Africa won 4–1 on aggregate and advanced to the third round.