2018 Fergana Challenger – Men's singles

Ilya Ivashka was the defending champion but chose not to defend his title.

Nikola Milojević won the title after defeating Enrique López Pérez 6–3, 6–4 in the final.

Seeds
• # 🇷🇸 Nikola Milojević (champion)

• # 🇪🇸 Enrique López Pérez (final)

• # Gonçalo Oliveira (second round)

• # 🇰🇷 Lee Duck-hee (second round)

• # 🇷🇺 Ivan Nedelko (second round, withdrew)

• # 🇧🇾 Egor Gerasimov (semifinals)

• # 🇩🇴 Roberto Cid Subervi (second round)

• # 🇯🇵 Yosuke Watanuki (quarterfinals)