2018 Internationaux de Tennis de Vendée – Singles

Elias Ymer was the defending champion and successfully defended his title, defeating Yannick Maden 6–3, 7–6(7–5) in the final.

Seeds
• # 🇫🇷 Benoît Paire (second round)

• # 🇷🇸 Laslo Đere (first round)

• # 🇫🇷 Ugo Humbert (first round, retired)

• # 🇨🇦 Félix Auger-Aliassime (withdrew)

• # 🇱🇹 Ričardas Berankis (second round, withdrew)

• # 🇩🇪 Yannick Maden (final)

• # 🇸🇪 Elias Ymer (champion)

• # 🇮🇹 Stefano Travaglia (second round)