2018 Internazionali di Tennis Città di Perugia – Singles

Laslo Đere was the defending champion but chose not to defend his title.

Ulises Blanch won the title after defeating Gianluigi Quinzi 7–5, 6–2 in the final.

Seeds
• # 🇦🇹 Gerald Melzer (first round)

• # 🇪🇸 Pablo Andújar (first round)

• # Blaž Kavčič (withdrew)

• # 🇪🇸 Enrique López Pérez (first round)

• # 🇷🇸 Nikola Milojević (second round, retired)

• # 🇮🇹 Matteo Donati (second round)

• # 🇭🇺 Attila Balázs (semifinals)

• # 🇪🇸 Carlos Taberner (second round)

• # 🇫🇷 Kenny de Schepper (second round)