2018 Internazionali di Tennis d'Abruzzo – Singles

Pedro Sousa was the defending champion but chose not to defend his title.

Gianluigi Quinzi won the title after defeating Casper Ruud 6–4, 6–1 in the final.

Seeds
• # 🇧🇪 Ruben Bemelmans (first round)

• # 🇮🇹 Stefano Travaglia (first round)

• # Gastão Elias (withdrew)

• # 🇮🇹 Simone Bolelli (withdrew)

• # 🇬🇧 Liam Broady (second round)

• # 🇨🇦 Félix Auger-Aliassime (second round)

• # Viktor Galović (second round)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇮🇹 Salvatore Caruso (first round)