2018 Italian Open – Women's singles

Defending champion Elina Svitolina defeated Simona Halep in a rematch of the previous year's final, 6–0, 6–4 to win the women's singles tennis title at the 2018 Italian Open.

Halep and Caroline Wozniacki were in contention for the WTA no. 1 singles ranking at the beginning of the tournament. Halep retained the top ranking when Wozniacki lost in the quarterfinals.

This tournament marked the retirement of former US Open finalist Roberta Vinci. She lost in the first round to Aleksandra Krunić.

Seeds
The top eight seeds received a bye into the second round. • 🇷🇴 Simona Halep (final)

• Caroline Wozniacki (quarterfinals)

• 🇪🇸 Garbiñe Muguruza (second round)

• 🇺🇦 Elina Svitolina (champion)

• Jeļena Ostapenko (quarterfinals)

• 🇨🇿 Karolína Plíšková (second round)

• 🇫🇷 Caroline Garcia (quarterfinals)

• 🇺🇸 Venus Williams (third round)

• 🇺🇸 Sloane Stephens (third round)

• 🇨🇿 Petra Kvitová (withdrew)

• 🇩🇪 Angelique Kerber (quarterfinals)

• 🇺🇸 CoCo Vandeweghe (first round)

• 🇺🇸 Madison Keys (third round, withdrew)

• 🇷🇺 Daria Kasatkina (third round)

• Anastasija Sevastova (third round)

• 🇦🇺 Ashleigh Barty (first round)

• 🇸🇰 Magdaléna Rybáriková (first round)

Seeds
• # 🇷🇸 Aleksandra Krunić (qualifying competition, lucky loser)

• # 🇧🇾 Aryna Sabalenka (qualifying competition, lucky loser)

• # 🇧🇪 Alison Van Uytvanck (qualified)

• # 🇺🇸 Danielle Collins (qualified)

• # Donna Vekić (qualified)

• # 🇨🇿 Kateřina Siniaková (qualifying competition)

• # Hsieh Su-wei (qualified)

• # 🇰🇿 Zarina Diyas (qualifying competition, lucky loser)

• # 🇮🇹 Camila Giorgi (qualifying competition)

• # 🇧🇾 Aliaksandra Sasnovich (first round)

• # 🇪🇪 Kaia Kanepi (qualified)

• # 🇷🇴 Monica Niculescu (withdrew)

• # Polona Hercog (qualified)

• # 🇨🇳 Wang Qiang (qualifying competition)

• # Monica Puig (qualifying competition, retired)

• # 🇵🇱 Magda Linette (first round)

Qualifiers
• # Polona Hercog

• # 🇷🇺 Natalia Vikhlyantseva

• # 🇧🇪 Alison Van Uytvanck

• # 🇺🇸 Danielle Collins

• # Donna Vekić

• # 🇪🇪 Kaia Kanepi

• # Hsieh Su-wei

• # 🇦🇺 Ajla Tomljanović

Lucky losers
• # 🇷🇸 Aleksandra Krunić

• # 🇧🇾 Aryna Sabalenka

• # 🇰🇿 Zarina Diyas