2018 J&T Banka Prague Open – Singles

Mona Barthel was the defending champion, but lost in the first round to Antonia Lottner.

Petra Kvitová won the title, defeating Mihaela Buzărnescu in the final, 4–6, 6–2, 6–3.

Seeds
• #🇨🇿 Karolína Plíšková (withdrew)

• #🇨🇿 Petra Kvitová (champion)

• #🇷🇺 Daria Kasatkina (first round)

• #🇦🇺 Daria Gavrilova (first round, retired)

• #🇨🇿 Barbora Strýcová (first round)

• #🇨🇳 Zhang Shuai (semifinals)

• #🇷🇴 Mihaela Buzărnescu (final)

• #🇨🇿 Kateřina Siniaková (quarterfinals)

• #🇧🇾 Aliaksandra Sasnovich (first round)

Seeds
• # Stefanie Vögele (qualified)

• # 🇯🇵 Miyu Kato (first round)

• # 🇩🇪 Tamara Korpatsch (qualifying competition, lucky loser)

• # 🇮🇹 Jasmine Paolini (qualifying competition, lucky loser)

• # 🇷🇺 Anna Kalinskaya (first round, retired)

• # Patty Schnyder (qualified)

• # 🇩🇪 Antonia Lottner (qualified)

• # 🇺🇦 Marta Kostyuk (first round)

Qualifiers
• # Stefanie Vögele

• # 🇷🇴 Elena-Gabriela Ruse

• # Patty Schnyder

• # 🇩🇪 Antonia Lottner

Lucky losers
• # 🇩🇪 Tamara Korpatsch

• # 🇮🇹 Jasmine Paolini