2018 JSM Challenger of Champaign–Urbana – Singles

Tim Smyczek was the defending champion but chose not to defend his title.

Reilly Opelka won the title after defeating Ryan Shane 7–6(8–6), 6–3 in the final.

Seeds
• # 🇪🇸 Marcel Granollers (second round)

• # 🇫🇷 Ugo Humbert (first round)

• # 🇨🇦 Peter Polansky (second round)

• # 🇺🇸 Reilly Opelka (champion)

• # Henri Laaksonen (first round, retired)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇺🇸 Christopher Eubanks (quarterfinals)

• # 🇦🇺 John-Patrick Smith (quarterfinals)