2018 Karshi Challenger – Singles

Egor Gerasimov was the defending champion and successfully defended his title.

Gerasimov won the title after Sergey Betov retired trailing 6–7(3–7), 0–2 in the final.

Seeds
• # 🇵🇱 Hubert Hurkacz (first round, retired)

• # 🇷🇸 Nikola Milojević (second round)

• # 🇧🇾 Egor Gerasimov (champion)

• # 🇧🇾 Uladzimir Ignatik (quarterfinals)

• # 🇰🇿 Aleksandr Nedovyesov (second round, retired)

• # Lloyd Harris (quarterfinals)

• # 🇧🇦 Aldin Šetkić (second round)

• # Yang Tsung-hua (second round)