2018 Knoxville Challenger

The 2018 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the fifteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Knoxville, United States between 5 and 11 November 2018.

Seeds

 * 1 Rankings are as of October 29, 2018.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Tennys Sandgren
 * 🇩🇪 Timo Stodder
 * 🇺🇸 Preston Touliatos
 * 🇺🇸 J. J. Wolf

The following player received entry into the singles main draw as a special exempt:
 * 🇺🇸 Tommy Paul

The following players received entry into the singles main draw as alternates:
 * 🇺🇸 Christian Harrison
 * 🇺🇸 Mitchell Krueger

The following players received entry from the qualifying draw:
 * 🇪🇨 Emilio Gómez
 * 🇺🇸 Michael Redlicki
 * 🇺🇸 Evan Song
 * 🇸🇪 Mikael Ymer

Singles

 * 🇺🇸 Reilly Opelka def. 🇺🇸 Bjorn Fratangelo 7–5, 4–6, 7–6(7–2).

Doubles

 * 🇯🇵 Toshihide Matsui / Frederik Nielsen def. 🇺🇸 Hunter Reese / 🇺🇸 Tennys Sandgren 7–6(8–6), 7–5.