2018 Las Vegas Challenger – Singles

Stefan Kozlov was the defending champion but lost in the first round to Kamil Majchrzak.

Thanasi Kokkinakis won the title after defeating Blaž Rola 6–4, 6–4 in the final.

Seeds
• # Lloyd Harris (second round)

• # 🇪🇸 Adrián Menéndez Maceiras (second round)

• # 🇳🇴 Casper Ruud (semifinals)

• # Jason Jung (quarterfinals)

• # 🇺🇸 Noah Rubin (first round)

• # 🇺🇸 Reilly Opelka (withdrew)

• # 🇩🇪 Dominik Köpfer (first round)

• # Marcelo Arévalo (second round)