2018 Nicholls Colonels football team

The 2018 Nicholls State Colonels football team represented Nicholls State University as a member of the Southland Conference during the 2018 NCAA Division I FCS football season. Led by fourth-year head coach Tim Rebowe, the Colonels compiled an overall record of 9–4 with a mark of 7–2 in conference play, sharing the Southland title with Incarnate Word. Nicholls State received the Southland's automatic bid to the NCAA Division I Football Championship, beating San Diego in the first round before losing to Eastern Washington in the second round. The team played home games at John L. Guidry Stadium in Thibodaux, Louisiana.

Preseason All-Conference Teams
On July 12, 2018, the Southland announced their Preseason All-Conference Teams, with the Colonels having a conference leading 14 players selected.

Offense first team
 * Chase Fourcade – Jr. QB
 * Damion Jeanpiere – Sr. WR
 * Ryan Hanley – Sr. OL
 * Chandler Arceneaux – Sr. OL

Defense first team
 * Sully Laiche – Jr. DL
 * Kenny Dotson – Sr. DL
 * Allen Pittman – Jr. LB
 * Hezekiah White – Sr. LB
 * Corey Abraham – Sr. DB
 * Ahmani Martin – Sr. DB

Offense second team
 * Kyran Irvin – Jr. RB
 * Dai'Jean Dixon – Sr. WR
 * Eddie Houston – Sr. OL
 * Lorran Fonseca – Sr. P

Preseason poll
On July 19, 2018, the Southland announced their preseason poll, with the Colonels predicted to finish in second place.