2018 Odlum Brown Vancouver Open – Women's singles

Maryna Zanevska was the defending champion, but lost to Nao Hibino in the second round.

Misaki Doi won the title after defeating Heather Watson 6–7(4–7), 6–1, 6–4 in the final.

Seeds
• # 🇺🇦 Kateryna Kozlova (second round)

• # 🇧🇪 Yanina Wickmayer (second round)

• # 🇷🇺 Ekaterina Alexandrova (first round)

• # 🇹🇳 Ons Jabeur (first round, retired)

• # 🇬🇧 Katie Boulter (quarterfinals)

• # 🇩🇪 Mona Barthel (withdrew)

• # Arantxa Rus (second round)

• # 🇧🇷 Beatriz Haddad Maia (second round)