2018 Open Castilla y León – Men's singles

Jaume Munar was the defending champion but chose not to defend his title.

Ugo Humbert won the title after defeating Adrián Menéndez Maceiras 6–3, 6–4 in the final.

Seeds
• # 🇺🇦 Sergiy Stakhovsky (first round)

• # 🇪🇸 Adrián Menéndez Maceiras (final)

• # 🇮🇹 Luca Vanni (semifinals)

• # 🇮🇹 Andrea Arnaboldi (semifinals)

• # Scott Griekspoor (first round)

• # 🇩🇪 Daniel Brands (quarterfinals)

• # 🇫🇷 Ugo Humbert (champion)

• # Tallon Griekspoor (withdrew)