2018 Open Sopra Steria de Lyon – Singles

Félix Auger-Aliassime was the defending champion and successfully defended his title.

Auger-Aliassime won the title after defeating Johan Tatlot 6–7(3–7), 7–5, 6–2 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (first round)

• # 🇦🇹 Gerald Melzer (first round)

• # Pedro Sousa (first round)

• # 🇪🇸 Pablo Andújar (second round, retired)

• # 🇫🇷 Quentin Halys (first round)

• # Henri Laaksonen (first round)

• # 🇷🇺 Alexey Vatutin (first round)

• # 🇫🇷 Corentin Moutet (first round)