2018 Rolex Paris Masters – Singles

Karen Khachanov defeated Novak Djokovic in the final, 7–5, 6–4 to win the singles tennis title at the 2018 Paris Masters. It was Khachanov's first Masters 1000 title, and he saved two match points en route, in his third round match against John Isner.

Jack Sock was the defending champion, but lost to Dominic Thiem in the quarterfinals. As a result, Sock fell out of the top 100 in the rankings after starting the season inside the top 10.

Rafael Nadal and Djokovic were in contention for the ATP No. 1 singles ranking. Djokovic regained the top spot after winning his opening match following Nadal's withdrawal from the tournament.

This tournament marked the first time since the 1998 Stuttgart Masters that no French or Spanish players reached the round of 16 of a Masters event.

Seeds
All seeds receive a bye into the second round. • 🇪🇸 Rafael Nadal (withdrew due to abdominal injury)

• 🇷🇸 Novak Djokovic (final)

• Roger Federer (semifinals)

• 🇩🇪 Alexander Zverev (quarterfinals)

• Marin Čilić (quarterfinals)

• 🇦🇹 Dominic Thiem (semifinals)

• Kevin Anderson (third round)

• 🇺🇸 John Isner (third round)

• 🇧🇬 Grigor Dimitrov (third round)

• 🇯🇵 Kei Nishikori (quarterfinals)

• Borna Ćorić (third round)

• 🇬🇧 Kyle Edmund (withdrew due to knee injury)

• 🇮🇹 Fabio Fognini (third round)

• Stefanos Tsitsipas (second round)

• 🇦🇷 Diego Schwartzman (third round)

• 🇺🇸 Jack Sock (quarterfinals)

Seeds
• # 🇦🇺 Matthew Ebden (qualifying competition, lucky loser)

• # Nicolás Jarry (first round)

• # 🇮🇹 Andreas Seppi (first round)

• # Robin Haase (qualified)

• # João Sousa (qualified)

• # 🇷🇸 Dušan Lajović (first round)

• # 🇩🇪 Jan-Lennard Struff (first round)

• # 🇹🇳 Malek Jaziri (qualifying competition, lucky loser)

• # 🇺🇸 Sam Querrey (first round)

• # 🇫🇷 Benoît Paire (qualified)

• # 🇩🇪 Peter Gojowczyk (qualified)

• # 🇺🇸 Tennys Sandgren (qualifying competition)

Qualifiers
• # 🇪🇸 Feliciano López

• # 🇩🇪 Peter Gojowczyk

• # 🇫🇷 Nicolas Mahut

• # Robin Haase

• # João Sousa

• # 🇫🇷 Benoît Paire

Lucky losers
• # 🇦🇺 Matthew Ebden

• # 🇹🇳 Malek Jaziri