2018 Samarkand Challenger – Singles

Adrián Menéndez Maceiras was the defending champion but chose not to defend his title.

Luca Vanni won the title after defeating Mario Vilella Martínez 6–4, 6–4 in the final.

Seeds
• # 🇺🇿 Denis Istomin (first round)

• # 🇭🇺 Attila Balázs (quarterfinals)

• # 🇷🇸 Nikola Milojević (semifinals)

• # 🇧🇾 Uladzimir Ignatik (semifinals)

• # Lloyd Harris (quarterfinals)

• # 🇰🇿 Aleksandr Nedovyesov (first round)

• # 🇧🇾 Egor Gerasimov (first round)

• # Yang Tsung-hua (quarterfinals)