2018 US Open – Girls' singles

Amanda Anisimova was the defending champion, but was chosen to compete in the women's singles instead as a wild card losing to Taylor Townsend in the first round.

Wang Xiyu won the title, defeating Clara Burel in the final, 7–6(7–4), 6–2.

Seeds
• # 🇺🇸 Cori Gauff (quarterfinals)

• # 🇺🇸 Alexa Noel (second round)

• # 🇨🇳 Wang Xiyu (champion)

• # 🇨🇴 Camila Osorio (semifinals)

• # 🇺🇸 Caty McNally (third round)

• # Clara Tauson (second round)

• # 🇱🇺 Eléonora Molinaro (first round)

• # 🇨🇦 Leylah Annie Fernandez (quarterfinals)

• # 🇯🇵 Naho Sato (quarterfinals)

• # 🇦🇷 María Lourdes Carlé (first round)

• # 🇫🇷 Clara Burel (final)

• # Joanna Garland (first round)

• # 🇮🇹 Elisabetta Cocciaretto (first round)

• # 🇨🇳 Zheng Qinwen (third round)

• # 🇺🇸 Katie Volynets (first round)

• # 🇺🇸 Lea Ma (third round)

Seeds
• # 🇭🇰 Cody Wong Hong-yi (qualifying competition)

• # 🇺🇸 Hurricane Tyra Black (qualified)

• # 🇹🇭 Mananchaya Sawangkaew (qualified)

• # 🇵🇱 Stefania Rogozińska Dzik (first round)

• # 🇺🇦 Daria Snigur (qualified)

• # 🇯🇵 Himari Sato (qualified)

• # 🇷🇺 Daria Frayman (qualifying competition)

• # 🇺🇦 Daria Lopatetska (qualified)

• # 🇷🇺 Anastasia Tikhonova (qualified)

• # 🇨🇴 Laura Sofía Rico García (first round)

• # 🇮🇹 Federica Sacco (qualifying competition)

• # 🇺🇸 Kacie Harvey (first round)

• # 🇮🇹 Melania Delai (first round)

• # 🇺🇸 Chloe Beck (first round)

• # 🇧🇬 Daniella Dimitrova (qualifying competition)

• # Joanne Züger (first round)

Qualifiers
• # 🇺🇸 Emma Jackson

• # 🇺🇸 Hurricane Tyra Black

• # 🇹🇭 Mananchaya Sawangkaew

• # 🇷🇺 Anastasia Tikhonova

• # 🇺🇦 Daria Snigur

• # 🇯🇵 Himari Sato

• # 🇧🇪 Victoria Kalaitzis

• # 🇺🇦 Daria Lopatetska