2018 US Open – Mixed doubles

Martina Hingis and Jamie Murray were the defending champions, but Hingis retired from professional tennis at the end of 2017. Murray successfully defended his title alongside Bethanie Mattek-Sands, defeating Alicja Rosolska and Nikola Mektić, 2–6, 6–3, [11–9] to win the mixed doubles tennis title at the 2018 US Open

Seeds
• # 🇨🇦 Gabriela Dabrowski / Mate Pavić (second round)

• # 🇺🇸 Nicole Melichar / 🇦🇹 Oliver Marach (quarterfinals)

• # Chan Hao-ching / 🇫🇮 Henri Kontinen (first round)

• # Latisha Chan /  Ivan Dodig (second round, withdrew)

• # 🇨🇿 Andrea Sestini Hlaváčková / 🇫🇷 Édouard Roger-Vasselin (quarterfinals)

• # Demi Schuurs /  Matwé Middelkoop (first round)

• # Katarina Srebotnik / 🇳🇿 Michael Venus (second round)

• # 🇺🇸 Abigail Spears / 🇨🇴 Juan Sebastián Cabal (second round)