2018 US Open – Wheelchair women's singles

Diede de Groot defeated the defending champion Yui Kamiji in a rematch of the previous year's final, 6–2, 6–3 to win the women's singles wheelchair tennis title at the 2018 US Open. It was her first US Open singles title, and was her second step towards a non-calendar-year Grand Slam.

Seeds
• # Diede de Groot (champion)

• #🇯🇵 Yui Kamiji (final)